Synthesis and Anticancer Activity Assay of Novel Chalcone-Sulfonamide Derivatives
نویسندگان
چکیده
Today Cancer remains to be one of the most deadly diseases in the world. Due to the potential anticancer activity of the chalcone and sulfonamide moieties, five novel hybrid compounds containing both structures have been designed and synthesized in 3 steps. The synthesized compounds were established on the basis of IR, 1H NMR, 13C NMR spectral data, and elemental analysis and also they were screened for in-vitro anticancer activity on human breast cancer cell line MCF-7. Among them, (E)-2-methoxy-N-(4-methoxyphenyl)-5-(3-(4-nitrophenyl) acryloyl) benzene sulfonamide (4) showed the most potent anticancer activity against MCF-7 cell line.
منابع مشابه
Synthesis and anticancer activity assay of novel chalcone sulfonamide derivatives
Chalcones, or 1,3–diaryl–2–propen–1–ones, one of the major classes of natural products and posses many useful properties like anticancer, antibacterial, antifungal, anti–inflammatory, antimalarial and anti–diabetic activity. We report in this communication the synthesis and anticancer study of a number of novel chalcone sulfonamides. Our results indicate that the synthesis of chalcone sulfonami...
متن کاملSynthesis and anticancer activity assay of novel chalcone sulfonamide derivatives
Chalcones, or 1,3–diaryl–2–propen–1–ones, one of the major classes of natural products and posses many useful properties like anticancer, antibacterial, antifungal, anti–inflammatory, antimalarial and anti–diabetic activity. We report in this communication the synthesis and anticancer study of a number of novel chalcone sulfonamides. Our results indicate that the synthesis of chalcone sulfonami...
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